She's put an enormous pile of papers on my desk and I haven't a clue what to do with them.
The post-war government had the enormous task of reconstructing the city.
She showed enormous courage when she rescued him from the fire.
He ran up an enormous phone bill by ringing up chatlines all the time.
Thus, an enormous block on a branch defined by a right endpoint can be essentially replaced by large subblocks corresponding to left endpoints.
Although there has been enormous progress toward accomplishing parts of the vision, the core problem - the design of ligands to bind proteins - has remained intractable.
In some cases these cancers are so rare that useful trials present enormous challenges.