Voorbeelden van reperfusion

• Although myocardial reperfusion can rescue the number of necrotic cardiac myocytes, it is critically dependent upon the time of intervention after ischaemic insult.

• The effect of oxygen radicals during reperfusion producing peroxidation and cellular injury is well described for other tissue beds during normothermia.

• And finally a reperfusion injury characterized by free radical formation and oxidative stress.

• This difference was particularly marked at 30 minutes, 60 minutes, and 90 minutes of reperfusion.

• Other laboratory studies have supported our finding of differential regional reperfusion.

• There are no additional studies, either animal or clinical, which discuss the time of reperfusion necessary to replete cerebral stores of energy to normal.

• The permeability of the blood-brain barrier was highly increased by ischemia/reperfusion.

• With the resumption of blood flow, the subsequent reperfusion produces large quantities of superoxide radical and hydrogen peroxide.

• Alternatively, excess formation of oxygen radicals after arrest associated with reperfusion may cause or exacerbate cerebral injury.

• Our findings of differential regional reperfusion following hypothermic circulatory arrest also have important implications.

• Addition of insulin to those solutions may be beneficial to protect immature myocardium from hypothermic, ischemic or reperfusion injury.

• Compared to sham controls, myelin processes began to degenerate at 12 hours reperfusion, with a significant loss of intact processes by 48 hours.

• Taken together, these findings illustrate that the brain has a heterogeneous response to ischemia and reperfusion injury.

• Following cerebral ischemia and reperfusion there is a downregulation of the protein synthesis machinery and translation arrest.

• Rewarming is commenced, and, during reperfusion, pacemaker wires are placed on the atrium and ventricle, and a pulmonary venous catheter is inserted.