0 the way in which genes change and produce permanent differences: --
1 the change that happens in an organism’s genes which produces differences that are passed to new organisms by reproduction, or the process of this change --
No mutations or polymorphisms were detected, but our primer pairs and reaction conditions may prove useful for future mutational analyses.
We did not detect any mutations or polymorphisms in any of the patients or controls.
Causative mutations were not found in two of the eight patients.
In more detailed analyses, several groups tested individual codons for replacement mutations that are, as an aggregate, overabundant.
Such replacement mutations are determined to be positively selected.
In a coding region, we intuitively expect to see mutations that make conservative amino acid substitutions; in particular, we expect an abundance of synonymous mutations.
Importantly, mutations in individual coiled-coil proteins lead to specific developmental or even behavioral phenotypes.
Two control samples were included in each experiment to normalize for mutations induced by transfection or superinfection processes.
