0 a rare bone cancer that grows slowly and usually develops along the spine or at the base of the skull --
Furthermore, germ line duplication of brachyury confers major susceptibility to chordoma.
Chordomas are relatively radioresistant, requiring high doses of radiation to be controlled.
The proximity of chordomas to vital neurological structures such as the brain stem and nerves limits the dose of radiation that can safely be delivered.
This suggests that some people may be genetically predisposed to develop chordoma.
This approach is used to remove chordomas, chondrosarcoma, inflammatory lesions of the clivus, or metastasis in the cervical spine region.
Chondroid chordomas appear to have a more indolent clinical course.
While most people with chordoma have no other family members with the disease, rare occurrences of multiple cases within families have been documented.
