Exempel på chordoma

• While most people with chordoma have no other family members with the disease, rare occurrences of multiple cases within families have been documented.

• Chondroid chordomas appear to have a more indolent clinical course.

• This approach is used to remove chordomas, chondrosarcoma, inflammatory lesions of the clivus, or metastasis in the cervical spine region.

• This suggests that some people may be genetically predisposed to develop chordoma.

• The proximity of chordomas to vital neurological structures such as the brain stem and nerves limits the dose of radiation that can safely be delivered.

• Chordomas are relatively radioresistant, requiring high doses of radiation to be controlled.

• Furthermore, germ line duplication of brachyury confers major susceptibility to chordoma.