That trial is expected to be expanded into a multi-center international study within the next year.
The three say they have "a fundamental difference in interpretations" over what doctors knew about how to treat preemies at the time the multicenter study was launched, back in 2004.
Analysis is required of similar large multicenter trials to confirm these conclusions.
However, it may be worthwhile that certain center characteristics are recorded to assist in the interpretation of multicenter data.
Finally, it has been argued that multicenter evaluations are likely to yield superior estimates to those derived from single-center studies (8).
Lead-in studies were similarly designed phase 3, multicenter, randomized, double-blind, placebo-controlled trials.
This was a multicenter, open-label, flexible-dose study of cariprazine 3–9 mg/d in adults with schizophrenia.
In a refined 8-week multicenter replication, the results were similar.
