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That trial is expected to be expanded into a multi-center international study within the next year.
The three say they have "a fundamental difference in interpretations" over what doctors knew about how to treat preemies at the time the multicenter study was launched, back in 2004.
Analysis is required of similar large multicenter trials to confirm these conclusions.
However, it may be worthwhile that certain center characteristics are recorded to assist in the interpretation of multicenter data.
Finally, it has been argued that multicenter evaluations are likely to yield superior estimates to those derived from single-center studies (8).
Lead-in studies were similarly designed phase 3, multicenter, randomized, double-blind, placebo-controlled trials.
This was a multicenter, open-label, flexible-dose study of cariprazine 3–9 mg/d in adults with schizophrenia.
In a refined 8-week multicenter replication, the results were similar.
An additional 38 (24%) were cooperative group, multicenter oncology protocols.
Such models can only be developed based on larger multicenter trials.
A multicenter, randomized, controlled clinical trial was performed.
Of the studies, 66 (73%) were single-center and 25 (27%) were multicenter studies.
One prospective, non-randomized, non-controlled, multicenter, clinical trial with two publications was retrieved.
In this multicenter, double-blind trial, patients were randomized to oral ximelagatran 24 mg twice daily (n= 612) or placebo (n= 611) for 18 months.
Compounding this problem, trial sponsors ask the health institutions that host multicenter clinical trials not to independently evaluate the studies’ scientific merit or ethical soundness.
