0 the level of poison contained in a drug, or the ability of a drug to poison the body: --
1 the quality of being poisonous, or the degree to which something is poisonous --
2 the fact that something is poisonous or the degree to which it is poisonous: --
Formation of insoluble aggregates might also re p re s e n t a cellular mechanism to diminish toxicity of intermediate products of aggregation.
More-specific receptor inhibitors could offer a better trade-off between efficacy and toxicity.
To assess the toxicity and efficacy of the combination of docetaxel and gemcitabine every 2 weeks as first-line therapy in metastatic breast cancer.
No frank clinical toxicity was observed, though both artesunate and artelinate induced doserelated vascular necrosis at the site of injection.
In particular, mixtures of heavy metals have been shown to have a significant, if variably, different impact on miracidia compared to single metal toxicity.
Such toxicities can become dose-limiting, leading to modifications in treatment and to insufficient tumour reduction.
To compare the hematological toxicity and efficacy of sequential versus concomitant administration of doxorubicin and docetaxel as metastatic breast cancer first-line treatment.
Severe skin reactions are those which fall within categories 3 and 4 and these are counted together to represent major toxicities.
