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Thus, there may be an evolutionarily conserved asymmetry in the metaphase checkpoint, which may reveal something about its mechanism.
Checkpoint proteins are crucial for cellular responses to injury, including radiation damage.
Obviously, a processor can always transmute into a checkpoint by just standing still.
We conclude, therefore, that the replication-sensitive checkpoints that operate during mitosis are absent or inactive during meiosis.
An extension of this examined the possibility of checkpoints during meiosis itself, specifically during metaphase.
We cannot exclude the possibility that the spindle assembly checkpoint acts during the first mitosis.
Meiotic spindle and spindle checkpoint proteins are responsible for normal chromosome alignment and separation during meiosis.
In this study, we addressed the developmental activation of the metaphase checkpoint in the zebrafish embryo.
If the understanding of checkpoint regulation during early embryonic mitotic cell cycles is limited, similar information is totally lacking concerning meiosis.
This checkpoint therefore provides time for mechanisms of restitution to function and prevent mitotic catastrophe.
It is not known, however, whether the same checkpoint exists in porcine zygotes.
These results imply the existence of checkpoint regulators which recognise early metaphase molecules and as a result delay meiotic progression.
The metaphase checkpoint will produce a reversible metaphase arrest in many different cell types.
However, news reports indicate that police forces were more interested in mounting illegal checkpoints and extorting bribes from civilians than in maintaining law and order.
The second checkpoint is 'positive selection', which occurs after selection has signalled the cell to rearrange the chain genes.
