With the development of sublingual immunotherapy tablets, allergen immunotherapy entered the era of evidence-based medicine.
The side-effects in the sublingual immunotherapy group were similar in type and frequency to those in the placebo group.
Sublingual immunotherapy may be somewhat safer, but less effective.
In 1986, the results of the first double-blind, placebo-controlled randomized clinical trial of house dust mite allergen sublingual immunotherapy were published.
Other oral formulations such as packets of effervescent powder, sublingual drops, elixirs and the like are also available in many places.
They develop from epithelial buds in the sulcus surrounding the sublingual folds on the floor of the mouth, lateral to the developing submandibular gland.
Nicotine gum, nicotine sprays, nicotine sublingual tablets, and nicotine lozenges administer nicotine orally.
Inhalation of an aerosolised extract is the method most favoured but sublingual administration or administration by a pessary or a suppository must not be overlooked.
