Management of mitochondrial myopathies remains largely symptomatic.
The inherited metabolic myopathies do not present for the first time in older people.
Muscular involvement may be manifested as a distal myopathy with later involvement of the proximal muscles, or as limb-girdle myopathy with distal progression.
On the other hand, chronic use of steroids is another important cause of proximal myopathy in older people.
Because of their increasing usage, we are seeing many more cases of statin-induced myopathy.
This is the commonest acquired myopathy in the elderly.
Cardiac complications, especially arrhythmias and myopathy, are the main cause of death.
Abnormal post-translational protein modifications also occur in myofibrillar myopathies, particularly as a result of oxidation and nitration.
