In healthy women, circulating ghrelin exhibited a drastic decrease after the food intake whereas, in bulimic patients, this response was significantly blunted.
Moreover, no significant correlation emerged between preprandial plasma ghrelin concentrations and its maximum percent decrease after the meal.
Moreover, we observed that, in untreated symptomatic bulimic women, the suppression of circulating ghrelin by food intake was significantly blunted.
A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children.
They report a new finding, blunting of the normal marked ghrelin decrease in bulimic women compared with healthy controls.
The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion.
All these findings suggest that ghrelin is a starvation-related hormone functioning as an indicator of shortterm changes in the energy balance.
Increased fasting plasma ghrelin levels in patients with bulimia nervosa.
