A binding site identified by these assays, however, does not necessarily represent a functional target in vivo.
Residues outside the binding site are represented by surface plot.
The charges are shown arranged nonspecifically to emphasize that such a mechanism is not dependent upon the existence of a specific binding site or pocket.
This is a strong argument for a binding site outside the pore.
As documented above, one is where the short motifs overlap and combine to perform a single binding site.
These regions have been classified by the strength with which water is bound and the nature of the binding site.
Favorable positions of functional groups in a binding site can be found and even novel minima, which are not present in the fixed structure.
More experiments investigating the nucleoside specificity of this binding site is under progression in our laboratory.
