However, tumour recurrence and progression to chemoresistance is usual and high-grade serous carcinomas account for a disproportionately high percentage of deaths due to ovarian cancer.
This leads to serous detachment of the retina, haemorrhage and ultimately scarring which is visible on fundoscopy and results in loss of vision.
The ability to reliably identify high-grade serous carcinomas has opened the way for subtype-specific studies on molecular events during oncogenesis.
With a median follow-up of 8 years, two women developed papillary serous peritoneal carcinoma after oophorectomy and 58 controls were diagnosed with ovarian cancer.
Finally, it is also possible that the variable responses of high-grade serous carcinomas to chemotherapy could be related to differing proportions of subpopulations of cancer cells with stem-cell-like features.
Genetic testing takes many weeks and currently can not be used to guide therapy in patients presenting with high-grade serous carcinoma, where there is an urgent need to initiate chemotherapy.
Should he not know how serous the situation is?
Not to safeguard sufficient space for this purpose would be a serous failure to accept our responsibility for the future.
