In collagen gels and in brain slices, both cell types developed neuronal-like processes with ruffling membranes and filopodia.
During migration, the cells extend filopodia, and there is extensive ruffling at the leading edge.
Again, long ruffling protrusions extend from the cell bodies.
Leading lamellae were frequently observed and it was often possible to identify ruffling edges.
The outer membrane showed ruffling and in some instances two membrane profiles were observed.
No noticeable modification such as membrane ruffling, actin microfilament reorganisation or tyrosine phosphorylation is detected in the host cytoskeleton.
Shape changes included extension of filopodia, ruffling of the edges, overall flattening of the cells, and obvious rapid movement.
The video shows the switch of a round cell, which bears blebs and filopodia, to a spread cell with ruffling activity.
