In summary, we have demonstrated that brimonidine is effective in protecting against ischemic retinal injury and in preserving retinal function.
This was accomplished prior to retinal impalement to align stimuli with the center of cells' receptive fields.
This difference is consistent with the known effects of dopamine upon the size of the receptive fields of retinal horizontal cells.
However, the stochastic nature of impulse trains leads to some unexpected effects in retinal coding.
It is also unclear whether retinal waves are responsible for generating fine retinotopy during development.
We find that the effects of sawtooth adaptation are different in each condition, presumably due to differences in the circuitry of the underlying retinal pathways.
It would also have implications for identifying the central pathways conveying the visual information, and hence for the retinal sources.
All visual behaviors were absent or greatly diminished until 8 to 10 weeks, when retinal layering had returned.
