The challenge has come from what was supposed to be the heart of the mechanistic world view - from physics.
Instead, a substantial part of the research has been dominated by an implicitly mechanistic and rationalistic approach.
The more predictable and mechanistic, the better - with allowances for elegant variation, as we shall see.
Evolutionary models suffer from two main problems: the characterisation of past and present mechanistic accounts of transformation.
And on the other hand, there is a small cadre of educated, scientific sorts who somehow manage to rise above this mechanistic cascade.
The account complements the more common mechanistic models.
The logic behind the order of the chapters escapes me, perhaps some of the mechanistic chapters could have come before the individual diseases chapters.
However, as they point out, this account is essentially a mechanistic one.