an islet in the San Blas archipelago
1 one of many groups of cells in the pancreas that produce hormones such as insulin
Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.
This narrows the density difference between islet and exocrine tissue.
Microencapsulation has been used to prevent rejection of islet xenografts, although the species combinations used are normally not directly applicable to clinical practice.
Furthermore, clinical islet transplantation is severely hampered by the lack of sufficient donor tissue.
Transplantation of pancreatic islets is arguably the most logical approach to restoring metabolic homeostasis in people with diabetes.
Furthermore, all of the islets do not separate completely from exocrine tissue during collagenase digestion, and this reduces the islet yield further.
In experimental animal models, these d i v e r s e methods have all been successful in inducing long-term acceptance of islet allografts.
There is a chronic shortage of human pancreas tissue suitable for either whole pancreas or islet transplantation.
