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A reasonable therapeutic strategy may be to suppress the aggregation of these proteins using compounds that inhibit their corresponding proteases.
Extracellular matrix : a tool for defining the extracorporeal function of parasite proteases.
Multiple proteases may also be involved in the degradation of the many protein precursors found in the developing seed.
Specific binding of normal prion protein to the scrapie form via a localized domain initiates its conversion to the protease-resistant state.
Alternative protein supplements were tested to determine possible specificity in the elicitation of these proteases.
These observations may explain the increasing attention addressed to cysteine proteases of parasites.
Some of the transcripts identified in this study are obvious choices, such as potential virulence factors, including proteases and various allergen-related proteins.
The serine protease inhibitor canonical loop conformation : examples found in extracellular hydrolases, toxins, cytokines and viral proteins.
Mammalian cell death proteases: a family of highly conserved aspartate specific cysteine proteins.
The third step is acquisition of protease resistance and takes place several hours after acquisition of detergent insolubility.
After destaining, proteases were located as clear bands in a blue background.
Insulin-like growth factor binding proteins in maternal serum throughout gestation and in the puerperium: effects of a pregnancy-associated serum protease activity.
Indeed, inhibition was higher when protease inhibitors were tested separately.
Several protease inhibitors were also tested under these conditions.
Because of the ubiquity of cysteine proteases in both protozoan and helminth parasites, they represent attractive targets for anti-parasitic drug development.
