Exempel på neuropathic

• Diabetic ulcers are often caused by recurrent pressure in neuropathic extremities and may be complicated by diminished blood flow in small and larger vessels.

• It was therefore hypothesized that patients with neuropathic and non-neuropathic pain have different profiles of symptoms and signs.

• Damage to peripheral nerves following either trauma or disease has several consequences including the development of neuropathic pain.

• Most commonly used animal models of neuropathic pain are induced by nerve injuries.

• In addition to this early model, ample recent evidence exists for changes in thalamic physiology in subjects with neuropathic pain.

• Neuropathic pain is induced within 3 days (early phase), fully established at 10 days (mid phase) and maintained at 21 days (late phase).

• Investigating the neuropathic elderly patient requires focusing on the most likely, rather than all possible, potential causes.

• Damage to the nervous system often causes neuropathic pain.

• Given that proinflammatory cytokines are implicated strongly in neuropathic pain, previous research has explored a potential therapeutic role for anti-inflammatory cytokines in treating this condition.

• A randomized controlled trial of duloxetine in diabetic peripheral neuropathic pain.

• In summary, we have identified an existing drug that might be redirected for testing in neuropathic pain.

• Recently, evidence has accumulated that supports a role of spinal microglia in chronic pain, especially the development of neuropathic pain.

• The results of ongoing and planned studies will provide considerable additional data regarding its efficacy in these and other neuropathic pain conditions.

• An increasing number of recent clinical trials, however, have failed to demonstrate efficacy of various other treatments for neuropathic pain.

• It is also useful in treating pain related to nerve injury, or neuropathic pain.