Exempel på neurodegenerative

• This study demonstrates several aspects of the evolution of clinical trial methodologies to assess potentially disease-modifying agents in patients with neurodegenerative disorders.

• These observations suggest that the expression of astrocyte connexins varies during the progression of this neurodegenerative disease.

• Recent years have seen the identification of many genetic defects that underlie hereditary neurodegenerative disorders in humans.

• Microglia have been implicated in aging-related neurodegenerative disease, yet relatively little is known about how normal aging and chronic pathological states may affect microglial function.

• Consequently, insulin abnormalities may disrupt normal memory functioning and promote pathophysiological processes observed in patients with neurodegenerative disorders.

• Potentially reversible impairments are likely to precede the neurodegenerative changes that characterize dementia.

• Excitotoxicity appears to play a role in both neurodegenerative and cerebrovascular diseases.

• There is substantial evidence that such reactive and inflammatory responses make significant contributions to neuronal damage in neurodegenerative diseases.

• This may reflect an independent relationship or the interaction of neurodegenerative pathology with vascular changes.

• Other neurodegenerative diseases fail to support the proposal that amyloid fibrils are pathogenic.

• It is a neurodegenerative syndrome that involves a slow decline in various aspects of the nervous system and memory function.

• Underlying neurodegenerative processes, which may be pathological or age-related, are thought to be the most likely explanation.

• A distinction between healthy, activated microglia and dysfunctional, senescent cells is crucial when considering future approaches to maintain brain health and treat neurodegenerative disease.

• Information about how best to intervene in protein-misfolding disorders may result in principles applicable across many neurodegenerative disorders.

• These phenomena may correlate with overloading of memory capacity due to neurodegenerative changes.