Exempel på mutagenic

• Virtually all known aspects of genome instability following mutagenic insult resulting in transmitted germ line mutations in mammals are based upon specific locus mutation experiments.

• Additionally, estrogen-induced tumor induction may involve receptor-mediated cell proliferation with tumor initiation by genotoxic and mutagenic events.

• Several steps are potentially mutagenic, such as exposure to high cytosolic concentrations of ethylene glycol, and the extreme dehydration that is a requisite for vitrification.

• This is the first quantitative estimate of the mutagenic effect of cryopreservation on the germ line of a metazoan.

• Moreover, where hybrid dysgenesis and mutagenic agents result in similar yet quantitatively variable genetic aberrations, accurate correlations are difficult to determine.

• Reports of hazardous chemical exposures to both male and female workers and related carcinogenic, mutagenic and now teratogenic effects are ever-increasing.

• Such protection will necessarily have reduced the exposure of bacteria to the potentially mutagenic ultraviolet and other radiation.

• This agent is a well-known carcinogen with conflicting indications of its mutagenic activity.

• Before cryopreserved embryos can be used for such studies, it is first necessary to show that cryopreservation is not mutagenic.

• A number of studies have shown that interactions between mutagenic chemicals and trematode infections can increase the risk of tumour development.

• Such resistance functions inhibit the uptake of drugs, inactivate the drugs before their interaction with cellular targets or repair lesions caused by the toxic or mutagenic effects of the drugs.

• Thus, our data suggest that the two genotypes may differ in their mutation rates, but provide no evidence that cryopreservation or storage of embryos is mutagenic.

• Other than tests for various genotoxic endpoints, including mutagenic and related responses, there has not been cross-agency acceptance of tests based upon in vitro and lower life forms.

• These oils contain certain quantities of polycyclic aromatic hydrocarbons, which are classified as carcinogenic, mutagenic and reprotoxic substances, as well as persistent organic pollutants.

• I am thinking in particular of carcinogenic, mutagenic or toxic substances that are known to be harmful.