Exempel på ischaemia

• In preeclampsia, an inadequate placental trophoblast invasion of the maternal uterine spiral arteries results in poor placental perfusion, leading to placental ischaemia.

• During ischaemia, when oxygen supply is limited, the electron transport chain of the inner mitochondrial membrane becomes highly reduced.

• When tissues undergo ischaemia followed by the re-establishment of blood flow, leukocytes are key players in causing the resultant tissue injury.

• Both effects could theoretically contribute to ischaemia-reperfusion type injury of the placenta, but assessing their importance in vivo is complex.

• There was no clinical evidence of myocardial ischaemia in either case.

• As yet, there is no treatment for macular ischaemia.

• The amount of retinal ischaemia that is present will limit the potential treatment benefit.

• This process, in addition to sustained or episodic hypotension may induce cerebral hypoperfusion, ischaemia and hypoxia.

• Coronary artery disease can give rise to reversible diastolic dysfunction during periods of acute ischaemia in elderly patients.

• Increased intracellular calcium is an important early factor in the cell damage seen in cerebral ischaemia.

• The combination of asphyxia and ischaemia due to hypotension and hypoperfusion results in a decrease of cerebral oxygen consumption and, if sustained, brain damage.

• Pathophysiology of hypertension during preeclampsia linking placental ischaemia with endothelial dysfunction.

• The potential antioxidant and neuroprotective properties are offset by the theoretical risk of cerebrovascular ischaemia.

• Critical limb ischaemia with peripheral neuropathy is a frequent complication in diabetes.

• Nevertheless, in an attempt to produce pre-eclampsia in animals, investigators have experimentally induced uteroplacental ischaemia in a variety of species.