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Homozygous mutants with only 2 % residual enzyme activity were recovered in progeny of inter se matings of heterozygotes.
Finally, rescue of adult viability was noted for homozygous males of several excision lines, in both enhancer-trap strains.
This mutation is semi-lethal since homozygous stocks display reduced viability (data not shown).
This type of plant-pathogen self-regulation is a characteristic of genetically diverse populations and is generally not found in homogeneous, homozygous monocultures.
In our case this hypothesis is not likely because no homozygous nulls were observed for the different loci analysed.
If these metabolic regulators are not involved, the transgenic mice and homozygous (lit\lit) mice would be expected to be identical to their wild-type littermates.
The average growth rate of the four (sometimes three, rarely two) wild-type homozygous (iw/iw) colonies was calculated.
When both loci are homozygous for a resistant allele, worms are highly resistant.
Two hundred and twenty-one independent lines were established by single-pair sibmating for 14 generations rendering independent homozygous lines.
The effect of a homozygous deletion in one of the alleles was correlated with higher antibody responses.
The first explanation is that the alleles which cause disease when homozygous, confer some benefit when heterozygous : this is the overdominance model.
