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Of the eight deaths observed on study, six were in the placebo group and two were in the creatine group.
The serum creatine kinase is grossly elevated, myoglobinuria may be evident, and there is a risk of acute renal failure.
However, if the diagnosis is suspected clinically, normal serum creatine kinase and electromyography should not put one off muscle biopsy.
Myopathies associated with marked elevation of the serum creatine kinase.
Another question was whether patients would compliant with respect to not taking additional creatine during the study.
Changes of creatine kinase secondary structure induced by the release of nucleotides from caged compounds - an infrared difference-spectroscopy study.
Maturational increase in mouse brain creatine kinase reaction rates shown by phosphorous magnetic resonance.
Conversely, weakness in hyperthyroidism is more evident, and may be the presenting symptom, but the serum creatine kinase is usually normal or only slightly increased.
The duration of circulatory arrest had a marked influence on peak concentration of creatine kinase, presumably reflecting the severity of the cerebral ischemic insult.
But if the diagnosis is suspected clinically, normal serum creatine kinase and electromyography should not deter one from muscle biopsy.
However, echocardiography and myocardial creatine kinase levels indicated that these cases did not have significant myocardial involvement.
An elevated creatine phosphokinase does not occur and should lead to a search for an alternative diagnosis.
Paradoxically, it is associated with marked elevation of the serum creatine kinase.
In this study, mice were fed a diet supplemented with 2% creatine, and were injected with 22 mg/kg/day of minocycline intraperitoneally.
Fifty subjects were enrolled in the creatine group and 54 in placebo.
