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Scientists working with the World Health Organization have identified the cause of the deaths as a novel coronavirus.
The previously unknown coronavirus is believed to have originated in animals before "jumping" to humans.
The coronavirus that causes Feline Infectious Peritonitis in cats was isolated.
Both patients had coronavirus infections.
These outbreaks establish this virus as a cause of morbidity in aged-care facilities and add to increasing evidence of the significance of coronavirus infections.
An outbreak was attributed to coronavirus when at least two respiratory specimens tested positive for the virus in the absence of other common respiratory pathogens.
However, no antigenic relationship to infectious bronchitis virus (an avian coronavirus) was detected.
There is still an ongoing discussion whether the responsible agent is close to the common cold or coronavirus.
Studies have revealed cis-acting elements and trans-acting viral factors involved in coronavirus genome encapsidation and packaging.
By the end of 2004, three independent research labs reported the discovery of a fourth human coronavirus.
Coronavirus infection of the intestinal villi makes the cells more susceptible to parvovirus infection.
Understanding the molecular mechanisms of genome selection and packaging is critical for developing antiviral strategies and viral expression vectors based on the coronavirus genome.
A more serious complication of canine coronavirus occurs when the dog is also infected with canine parvovirus.
Blood tests can also be performed to bolster a presumptive diagnosis by looking for coronavirus antibodies and elevated protein.
Feline coronavirus is typically shed in feces by healthy cats and transmitted by the fecal-oral route to other cats.
However, fatal intestinal disease associated with canine coronavirus without the presence of canine parvovirus is still occasionally reported.
Canine coronavirus was originally thought to cause serious gastrointestinal disease, but now most cases are considered to be very mild or without symptoms.
Clinically, the intestinal form of the infection can sometimes be confused with coronavirus or other forms of enteritis.
Torovirus particles share characteristics with other members of the coronavirus family; they are round, pleomorphic, enveloped viruses about 120 to 140 nm in diameter.
