Exempel på cisplatin

• Delayed emesis can persist up to five days after cisplatin administration, peaking in intensity at 48 to 72 hours.

• This balanced perspective on the impact of this novel could increase capacity in a service stretched to provide adequate cisplatin provision.

• The first cisplatin analog to be developed was carboplatin.

• The toxicity profile mirrored that of cisplatin alone with the most common toxicities being cytopenias (n 10), nausea/vomiting (n 9), and asthenia (n 5).

• Clinical trials have since established cisplatin in lung, ovarian, esophageal, cervical, head and neck and germ cell cancers.

• For this reason, cisplatin-induced emesis has become the human model by which antiemetic regimens are evaluated (7).

• Like other traditional chemotherapeutic agents, cisplatin has untoward side-effects (nephrotoxicity, ototoxicity, and neuropathy) and clinical drug resistance does occur.

• T he drugs best known t o cause anosmia are cisplatin and neuroleptic drugs.

• Acute emesis usually begins 2 to 4 hours after cisplatin administration and peaks at 6 hours (23;26).

• Unfortunately, carboplatin shows a marked degree of cross-resistance when compared to cisplatin.

• Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells.

• The results of our study show that cisplatin has no effect on either minisatellite mutations or crossover frequencies during the most important stages of mouse spermatogenesis.

• In the case of antineoplastic agents such as paclitaxel, cisplatin and thalidomide, the neuropathy is dose-dependent and doselimiting; patients often cannot tolerate the doses necessary to treat the underlying cancer.

• Carboplatin costs £205.71 against £17.90 for cisplatin, but the total treatment costs are reduced from £347.90 to £228.77.

• This research is especially useful for cancer patients because chemotherapy drugs, such as cisplatin, cause nausea and vomiting.