Exempel på allele

• For this analysis, rare alleles were combined, thereby reducing a total of 124 alleles over the six microsatellites down to 49 allele classes.

• It describes the dynamics of a wild-type allele and its variants, derived by mutation, for an infinitely large population.

• In microsatellites, repeat sequences of different lengths at a given locus are referred to as alleles and co-dominance is observed.

• In the four remaining polymorphisms, the rare allele is at most present in three sequences out of 20.

• Similarly, we did not perform sub-analyses of the e2 allele due to its relatively small frequency across age groups in the population.

• The same set of simulations also yielded allele numbers and diversity (expected heterozygosity) values at the neutral locus under the infinite alleles model.

• This is an artefact due to the particular combination of allele frequency distribution and error model adopted in the simulations.

• The age of an allele is the time since it arose by mutation.

• Similarly, increasing marker information for each sample (number of independent marker alleles, sample size) also results in better estimations (data not shown).

• Mutation-selection balance can be efficient in explaining the process of gene substitution only if one of these deleterious alleles acquires a relatively high selective advantage.

• Here we study the effect of population size on the inbreeding depression caused by mildly deleterious alleles.

• We found that the model has low statistical power when inbreeding depression is caused by the build-up of mildly deleterious alleles.

• Fixation for a haplotype corresponds to fixation of a deleterious allele at a particular locus.

• In fact, the preferential transmission of the 7-repeat allele from parents to disorganized children was not significant.

• It is customary to concentrate only on the transmitted marker allele.