Exempel på adrenalectomy

• This will need to be established using animal models that produce low baseline glucocorticoid concentrations without removing glucocorticoids entirely from systemic circulation (as is the case in adrenalectomy).

• During this process one or two adrenal glands can be removed and this is known as adrenalectomy.

• Following adrenalectomy, epinephrine disappears below the detection limit in the blood stream.

• Bilateral adrenalectomy is another treatment which provides immediate reduction of cortisol level and control of hypercortisolism.

• All of these conditions, with the exception of adrenalectomy, cause a large elevation of circulating aldosterone.