This may be accompanied by calcinosis, telangiectasia, loss of finger pulps and ulceration.
Some 30% of patients also have a number of typical extra-intestinal manifestations, which include arthritis, mouth ulceration and ocular inflammation.
Several theories have been suggested to explain the progression from thrombosis and incompetence to venous ulceration.
Very rarely erosion or ulceration has been reported.
Severity of ulceration and delay in response to treatment using standard care are important considerations in deciding who should receive therapy.
These deformities lead to abnormal patterns of weight-bearing with callus formation, and ulceration may develop.
Some babies do not take well to this intrusion at meal times, and many with wide clefts manage to feed well without ulceration.
Chosing a practical screening instrument to identify patients at risk for diabetic foot ulceration.
