0 the worst moment, or the moment of least hope and least achievement:
The city experienced an economic nadir in the 1970s.
Core body temperature rises gradually from its nadir in the middle of the night during slow-wave sleep, the least active brain state.
At the winter solstice we acknowledge the sun at its nadir and we beseech its return.
However, tomato plants had highly elongated and complex canopies that could not be easily measured from either a nadir or horizontal orientation.
In the run up to the first presidential election under the new constitution in 1965, relations between farmers and the government reached their nadir.
The incidence then falls, reaching a nadir around 45 years, and then increases steadily with age.
Immediately after birth, pulmonary resistance lowers progressively, reaching its nadir at 3 months.