motor neuron Význam & definícia

Príklady motor neuron

• Other features of motor neuron disease are generalized muscular weakness, wasting, fasciculation and brisk reflexes, though sensation is intact.

• Pathologically, at 120 days of age, mice treated with minocycline had reduced motor neuron loss, vacuolization, and microglial activation compared to control animals.

• Our mouse model of motor neuron degeneration will provide access to new genes involved in the pathology of these cells.

• Reduction of the naturally occurring motor neuron loss by enlargement of the periphery.

• The aetiology is likely to be multifactoral, involving interplay of several mechanisms to initiate disease and propagate the spread of motor neuron cell death.

• Experiments in transgenic mice have revealed a key role for neurofilaments in normal motor neuron function.

• The final mechanism of motor neuron death in amyotrophic lateral sclerosis is likely to be via a process resembling apopotosis.

• Here we review the evidence for the main pathogenic mechanisms and outline how they might interact to cause motor neuron death.