Prolonged hyperglycaemia due to impaired insulin effects is associated with the development of microvascular and macrovascular complications causing morbidity and premature mortality.
Estimated benefits of glycemic control in microvascular complications in type 2 diabetes.
The rigidity of these cells contributes to the overall process of microvascular occlusion that leads to tissue ischaemia and organ dysfunction.
Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy.
The exact significance of microvascular disease in the genesis of ulceration is uncertain at present.
The underlying mechanisms are not completely understood but both macro- and microvascular structures appear to be involved in addition to impaired autoregulatory mechanisms.
There may be other benefits of screening diabetic subjects than prevention of microvascular disease.
Microvascular complications are not explicitly incorporated into the model.
