0 a medical problem in which there is not enough blood flowing to a part of the body, usually because the arteries have become too narrow. It can lead to very serious health conditions:
cerebral/myocardial ischaemia
In preeclampsia, an inadequate placental trophoblast invasion of the maternal uterine spiral arteries results in poor placental perfusion, leading to placental ischaemia.
During ischaemia, when oxygen supply is limited, the electron transport chain of the inner mitochondrial membrane becomes highly reduced.
When tissues undergo ischaemia followed by the re-establishment of blood flow, leukocytes are key players in causing the resultant tissue injury.
Both effects could theoretically contribute to ischaemia-reperfusion type injury of the placenta, but assessing their importance in vivo is complex.
There was no clinical evidence of myocardial ischaemia in either case.
As yet, there is no treatment for macular ischaemia.
The amount of retinal ischaemia that is present will limit the potential treatment benefit.
This process, in addition to sustained or episodic hypotension may induce cerebral hypoperfusion, ischaemia and hypoxia.
