half-life Význam & definícia

Príklady half-life

• It is then inactivated by hemoglobin, giving it a very short elimination half-life.

• Fluvoxamine shows the least non-linearity of pharmacokinetic parameters, with half-life increasing from about 15 to 23 hours with multiple dosing.

• The authors reported rates of change to more appropriate therapeutic agents that were significantly greater than expected, and as high 40% for long half-life benzodiazepines.

• Entacapone has a similar half-life to levodopa and is usually given with each levodopa dose.

• It has a very long half-life of 3-5 days; its significant adverse-event profile requires extremely slow dose titration every 2- 3 weeks.

• The half-life of output rises from 13 years to 40 years as persistence increases from none to complete.

• Pharmacokinetic data are collected to determine the half-life, the maximum concentration area under-the-curve, and other parameters.

• A cyclotron is required to produce fluorine18, a radioisotope with a half-life of less than 2 hours (110 min), which makes storage impossible.