Dosing was adjusted to five times a day when rebound occurred.
Flexible dosing procedures were employed based on a given participant's weight and self-reported opiate use at intake.
The dosing schedule began at 2.5 mg/day of liquid fluoxetine or placebo once a day for 1 week.
Conventional dosing may produce higher serum concentrations than are seen in young adults.
Fluvoxamine shows the least non-linearity of pharmacokinetic parameters, with half-life increasing from about 15 to 23 hours with multiple dosing.
The results are sensitive to the dosing regimen adopted, the discontinuation rate, and assumptions concerning disease progression while on treatment.
The challenge will be to determine the duration of treatment required (3 years, 5 years or lifelong) and a safe dosing interval.
Dosing of contrast material to prevent contrast nephropathy in patients with renal disease.
