0 a hormone (= a chemical made in the body) that controls feelings of hunger and the way the body stores fat: --
The identification of the hormone leptin transformed obesity research.
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.
It is still unknown whether lifelong exercise can prevent the development of leptin resistance during aging.
Recombinant porcine leptin reduces feed intake and stimulates growth hormone secretion in swine.
However, prolonged caloric excess results in dysregulation of post-receptor leptin signalling.
Testosterone supplementation improved right grip strength and resulted in decreased leptin levels, with no change in body fat or body mass index.
There is also evidence to suggest that leptin, an adipose tissue-derived hormone, plays a role in both.
Some evidence suggests that prolonged exposure to the elevated level of leptin may play a causative role in agerelated leptin resistance.
Nevertheless, the essential observation was that leptin gene expression decreased with age, with the main difference occurring between 15 and 24 months.
