The tocopherol arm was continued but eventually failed to show efficacy.
Eight hundred patients were randomized to tocopherol/placebo or deprenyl/placebo, in a 2 2 factorial design.
Lipid peroxidation products and tocopherol were assayed on three replicate samples.
Immediately prior to measurements, the supernatant was evaporated to dryness under nitrogen and the tocopherol was redissolved in methanol.
Immediately prior to measurement, the supernatant was evaporated under nitrogen and the tocopherol was redissolved in methanol.
Ascorbate acts at the water-lipid interface to recycle tocopherol radical and thus inhibit the chain of lipid peroxidation.
In addition, there was a very similar, large increase in total tocopherol in both species.
Patients with secondary hyperparathyroidism associated with renal disease may respond to 1,25 dihydroxycholecalciferol or 1 tocopherol, or to partial parathyroidectomy.
