Some of these mutated forms of tumor suppressor genes are likely to have partial function or dominantnegative functions.
The merlin tumor suppressor localizes preferentially in membrane ruffles.
The cumulative inactivation of tumour suppressor genes and/or the amplification of oncogenes lead to progressively more malignant astrocytic tumours.
Repression of proliferation-associated genes by the formation of heterochromatin serves to block cellular division and so acts as a potent tumour suppressor mechanism.
However, in every case, the valence of the regression coefficient was of the same valence as the bivariate correlation, thus ruling out suppressor effects.
One could speculate that selection for suppressors of a wing mutation would be more critical to the species than suppressors of an eye colour mutant.
Methods of estimation using suppressor variables, curvilinear regression equations, qualitative differentiae, etc., have been discussed extensively.
Proteins related to nuclear proto-oncogene- and tumor suppressor geneproducts.
