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Powder for oral suspension contains sucrose and should not be used in patients with hereditary fructose, glucose/galactose malabsorption or sucrase-isomaltase deficiency.
Other brush border enzymes are maltase, sucrase and lactase.
Invertase is a sucrase used industrially for the hydrolysis of sucrose to so-called invert sugar.
Sucrase is secreted by the tips of the villi of the epithelium in the small intestine.
Sucrase is an enzyme that breaks down the disaccharide sucrose, commonly known as table sugar, cane sugar, or beet sugar.
As with other sugars, sucrose is digested into its components via the enzyme sucrase to glucose (blood sugar) and fructose.
In the small intestine, this enzyme works in synergy with sucrase-isomaltase and alpha-amylase to digest the full range of dietary starches.
If the enzyme sucrase is added, however, the reaction will proceed rapidly.
Sucrose is broken down during digestion into a mixture of 50% fructose and 50% glucose through hydrolysis by the enzyme sucrase.
In most cases, sucrose intolerance is an autosomal recessive, genetic, metabolic disease, and involves deficiency in the enzyme sucrase, which breaks apart the glucose and fructose molecules.
Sucrose intolerance ("congenital sucrase-isomaltase enzyme deficiency") can be caused by genetic mutations in which both parents must contain this gene in order for the child to carry the disease.
