Voorbeelden van scrapie

• Previous, often intensive control programmes have foundered, and we cannot point to a clear-cut example of successful large-scale scrapie control.

• In this paper we develop a method to fit stochastic transmission models to outbreak data and explore its use by analysing a high-incidence scrapie epidemic.

• At the within-flock level, we describe scrapie transmission using a stochastic model incorporating the available data on pathogenesis, sheep demography, genetic susceptibility and incubation times.

• Data are either right-censored for scrapie deaths, representing non-scrapie morality only (solid lines), or include scrapie mortality (broken lines).

• However, we note that the dynamics of the disease in goats is likely to be highly dependent on sheep scrapie.

• Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains.

• In future research, similar model analyses of data on less severe scrapie epidemics should provide more detailed information.

• Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters.

• This will serve as a starting point for the future study of scrapie persistence in a population consisting of a large number of interacting flocks.

• These data are simultaneously analysed using mathematical models describing scrapie transmission between sheep and between flocks.

• At present, given the uncertainities surrounding the transmission characteristics of scrapie, it is important to consider a broad variety of different transmission scenarios.

• During this period a total of 304 scrapie cases occurred.

• Below we will also compare the population-level prevalence of scrapie infection between various within-flock transmission scenarios.

• Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing.

• Of more interest is the prediction of the number of non-case farms that currently harbour undetected scrapie.