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The symptoms associated with myelofibrosis are variable and in more than 50% of patients include marked lassitude, loss of weight and night sweats.
This distinction is important since the treatment of polycythemia vera carries a serious risk of myelofibrosis and acute leukemia.
A leucoerythroblastic blood film, where nucleated red blood cells and early white cell forms appear, is strongly suggestive of myelofibrosis or marrow replacement by malignancy (both haematological and non-haematological).
The cause and risk factors for primary myelofibrosis are unknown.
Myelofibrosis is a myeloid malignancy associated with anemia, splenomegaly, and constitutional symptoms.
It is common in people who have chronic idiopathic myelofibrosis.
It is part of the presentation in acute panmyelosis with myelofibrosis.
Older terms include myelofibrosis with myeloid metaplasia and agnogenic myeloid metaplasia.
For the disease chronic idiopathic myelofibrosis, see myelofibrosis.
Hairy cell leukemia was originally described as histiocytic leukemia, malignant reticulosis, or lymphoid myelofibrosis in publications dating back to the 1920s.
Dacrocytosis can be associated with myelophthisic anemia, commonly caused by myelofibrosis.
Seen in bone marrow failure, myelofibrosis and extramedullary haemopoiesis.
Myelofibrosis is a form of myeloid metaplasia, and often the two terms are used synonymously.
She currently suffers from myelofibrosis, a bone-marrow disorder that affects the red blood cells.
In primary myelofibrosis, progressive scarring (fibrosis) of the bone marrow occurs, for the reasons discussed above.
