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In several series of mutagenicity experiments we have detected enzyme activity mutations causing haemolytic anaemia.
This hints at a process common to haemolytic disorders.
All patients should be started on folic acid replacement as folate requirements increase during haemolytic processes.
Haemolytic disease of the newborn is a case of special interest because the observed gene frequencies are not compatible with the apparent gene-selection process.
Isolates harbouring the act gene differed from act genedeficient ones with respect to haemolytic activity on blood agar plates.
If the haemolytic destruction of red cells is greater than the ability for the marrow to compensate, a haemolytic anaemia ensues.
As with any other chronic haemolytic anaemias, increased iron absorption from the gut, splenomegaly and gallstones occur.
These maternal antibodies will destroy fetal red cells giving rise to haemolytic disease of the newborn.
Side-effects, particularly haemolytic anaemia, must be watched for.
The enzyme activity level of these mice is comparable with that of human variants who show signs of haemolytic anaemia.
Antibody production was determined by the direct haemolytic plaque-forming cell assay.
Clinically, this deficiency was manifested by a haemolytic crisis precipitated by eating fava beans in the eldest daughter.
Haemolytic anaemia is an uncommon complication.
Drugs may also induce a haemolytic anaemia.
Two cases developed haemolytic-uraemic syndrome.
