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Gene amplification occurs in both oogenesis and spermatogenesis, the difference consisting in the ribosomal gene amplification mechanism.
Chronic treatment with physiological concentrations of ethanol (0.36%, 1.36%) induces micronuclei, nucleoplasmic bridges, and nuclear buds, which are indicative of chromosome loss and breakage, chromosome rearrangement and gene amplification, respectively.
Somatic recombination, gene amplification and cancer.
Overexpression can happen in one of three ways: as a result of gene amplification, impaired protein degradation, or chromosomal translocation.
Some scientists suggest that this result may have been caused by selection for gene amplification and/or a higher mutation rate in cells unable to divide.
