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Warfarin embryopathy includes nasal hypoplasia and/or stippled epiphyses.
As the castrato's body grew, his lack of testosterone meant that his epiphyses (bone-joints) did not harden in the normal manner.
The male growth spurt also begins later, accelerates more slowly, and lasts longer before the epiphyses fuse.
These various epiphyses are joined to the bone by the 25th year.
This disorder affects the epiphyses, the parts of the bone where growth occurs.
The remaining cartilaginous portions of the epiphyses become thinner.
With subadults, the development of teeth, length of long bones, and union of epiphyses are used to estimate age.
The ends of epiphyses are covered with hyaline cartilage (articular cartilage).
The epiphyses, carpal bones, coracoid process, medial border of the scapula, and acromion are still cartilaginous.
In long bones, the secondary centres appear in the epiphyses.
The tibia is categorized as a long bone and is as such composed of a diaphysis and two epiphyses.
As these cartilaginous zones become obliterated, the epiphyses are said to be closed and no further lengthening of the bones will occur.
Unlike pressure epiphyses, these regions do not assist in weight transmission.
Both had skeletal abnormalities of the hands and feet: brachydactyly, cone-shaped epiphyses, and an abnormal metaphyseal-phalangeal pattern profile.
Pressure epiphyses assist in transmitting the weight of the human body and are the regions of the bone that are under pressure during movement or locomotion.
