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Smallpox and cowpox are closely allied and the substances formed in the blood by the one are resistant to the virus of the other.
The disease becomes modified when transferred to cattle, producing what is known as cowpox, in which vesicles similar to those of smallpox appear on the skin.
The germ of cowpox, which is believed to be either the cow or horse variety of human smallpox, is cultivated upon healthy calves.
Prior to admission, all children were given a cowpox vaccination to prevent smallpox and the orphanages employed a doctor who provided the necessary medical care.
Viral inhibition of inflammation : cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme.
A total of five deaths from cowpox and post-vaccinal complications were registered during the period, one in 1948, two in 1950, and two in 1951.
He attempted to maintain a monopoly over the cowpox vaccine, for both financial reasons and to protect the vaccine from incompetent or fraudulent physicians.
He used cowpox to confer induced immunity on humans.
Scientists have not determined exactly when the change or mutation occurred, but the effects of vaccinia and cowpox virus as vaccine are nearly the same.
Jenner was not the first person to inoculate with cowpox nor the first to realize that infection with cowpox gave immunity to smallpox.
Other vaccine material was not reliably derived from cowpox, but from other skin eruptions of cattle.
At some point, the virus in use was no longer cowpox, but vaccinia.
Immunity to cowpox is gained when the smallpox vaccine is administered.
Vaccinia, cowpox, and monkeypox viruses can infect both humans and other animals in nature.
Cowpox is a poxvirus in the same family as variola.
This confirmed his childhood suspicion, and he studied cowpox further, presenting a paper on it to his local medical society.
Cowpox is similar to, but much milder than, the highly contagious and often deadly smallpox disease.
He deduced that cowpox was most likely to transfer immunity from smallpox if administered at the eighth day of the disease.
