Examples of myelin

• How these membrane domains evolve during myelin formation is unknown.

• This evidence indicates that this pathway has an essential role in early myelination events, and possibly in maintenance of myelin.

• Individual sections were stained for cell body (cresyl violet) and myelin.

• They also stained more intensely for myelin basic protein, implying that greater myelin content made the columns visible in dark field.

• These observations show that correct targeting and transport of the major myelin proteins are important for survival and myelination of oligodendrocytes.

• Each segment of axon wrapped by a compact portion of the myelin sheath corresponds to an internode.

• Finally, we detected two proteins that had not been shown previously to be present in myelin sheaths.

• Therefore, we have confirmed and expanded the compact myelin proteomic database by using a different methodological approach.