0 (especially in the past) an older person, especially a woman, who stays with and takes care of a younger woman who is not married when she is in public: --
1 (especially in the past) to stay with and take care of a young woman who is not married when she is in public: --
An open question is do such anti-parallel configurations exist in the physiological context and if so, are they regulated by chaperones ?
Molecular chaperones in the cytosol : from nascent chain to folded protein.
Despite these potential problems, the initial cell culture and clinical studies suggest that pharmacological chaperones offer an exciting new therapeutic strategy to treat genetic diseases.
Examples of processing mutants rescued by pharmacological chaperones are discussed below.
The advantages of pharmacological chaperones are that they can be specific and nontoxic, and can be used at much lower concentrations than chemical chaperones.
Initial clinical studies with pharmacological chaperones have successfully reduced clinical symptoms of disease.
Many researchers worldwide are attempting to determine the mechanism of action of these various molecular chaperones, many of which exist as families of related proteins.
Thus, i t was possible that these findings were not d u e to the molecular chaperones themselves, b u t to contaminating bacterial components.
