Примери за chaperone

• The reason for this is that, at present, there is no k n o w n mechanism to explain how cells can secrete molecular chaperones.

• Therefore, pharmacological chaperones show great promise as a new class of therapeutic agents that can be specifically tailored for a particular genetic disease.

• A related strategy for the treatment of various protein-misfolding disorders is to rescue folding defects with 'pharmacological chaperones'.

• The processing defects must be identified and tested to determine whether they can be rescued with pharmacological chaperones.

• Are the effects of multiple pharmacological chaperones additive or synergistic?

• In some cases, chaperones promote the correct folding of their misfolded protein substrates.

• The girl of the period demands increased liberties, including the right to entertain without chaperones, to wear cosmetics, and to dress in stylish fashions.

• Thus, i t was possible that these findings were not d u e to the molecular chaperones themselves, b u t to contaminating bacterial components.

• Many researchers worldwide are attempting to determine the mechanism of action of these various molecular chaperones, many of which exist as families of related proteins.

• Initial clinical studies with pharmacological chaperones have successfully reduced clinical symptoms of disease.

• The advantages of pharmacological chaperones are that they can be specific and nontoxic, and can be used at much lower concentrations than chemical chaperones.

• Examples of processing mutants rescued by pharmacological chaperones are discussed below.

• Despite these potential problems, the initial cell culture and clinical studies suggest that pharmacological chaperones offer an exciting new therapeutic strategy to treat genetic diseases.

• Molecular chaperones in the cytosol : from nascent chain to folded protein.

• An open question is do such anti-parallel configurations exist in the physiological context and if so, are they regulated by chaperones ?