Diabetic ulcers are often caused by recurrent pressure in neuropathic extremities and may be complicated by diminished blood flow in small and larger vessels.
It was therefore hypothesized that patients with neuropathic and non-neuropathic pain have different profiles of symptoms and signs.
Damage to peripheral nerves following either trauma or disease has several consequences including the development of neuropathic pain.
Most commonly used animal models of neuropathic pain are induced by nerve injuries.
In addition to this early model, ample recent evidence exists for changes in thalamic physiology in subjects with neuropathic pain.
Neuropathic pain is induced within 3 days (early phase), fully established at 10 days (mid phase) and maintained at 21 days (late phase).
Investigating the neuropathic elderly patient requires focusing on the most likely, rather than all possible, potential causes.
Damage to the nervous system often causes neuropathic pain.
